- 肝素类药物临床应用精要
- 张进华主编
- 3093字
- 2025-03-15 05:34:41
参考文献
[1]DAGER W E,GULSETH M P,NUTESCU E A.抗凝治疗医护指南[M].师少军,吕永宁,译.北京:人民卫生出版社,2012.
[2]李家增,王鸿利,包承鑫.抗血栓药和溶血栓药临床应用[M].北京:科学技术文献出版社,2009.
[3]GARCIA D A,BAGLIN T P,WEITZ J I,et al. Parenteral anticoagulants:Antithrombotic Therapy and Prevention of Thrombosis,9th ed:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines[J]. Chest,2012,141(2 Suppl): e24S-e43S.
[4]付朝宏,黄寿吾,顾其胜,等.血浆肝素浓度测定[J].血栓与止血学杂志,1994(2):73-75,82.
[5]ALBADA J,NIEUWENHUIS H K,SIXMA J J. Pharmacokinetics of standard and low molecular weight heparin[M]//Lane D A,Lindahl U.Heparin:chemical and biological properties,clinical applications. London: Edward Arnold,1989:417-431.
[6]洪霞,单培仁,黄伟剑,等.基于体重的肝素负荷剂量下体重指数对活化凝血时间的影响[J].心电与循环,2012,31(2):74-76.
[7]ALBAN S. From heparins to factor Ⅹa inhibitors and beyond[J].Eur J Clin Invest,2005,35 Suppl 1: 12-20.
[8]MOUSA S A,MANNA M. Pharmacokinetic differences among unfractionated heparin and low molecular weight heparins:Impact in patients with renal impairment[M]//PIYATHILAKE D E,LIANG R. Heparin:properties,uses and side effects. New York: Nova Science Publishers,2012:179-195.
[9]GRAY E,HOGWOOD J,MULLOY B. The anticoagulant and antithrombotic mechanisms of heparin[J]. Handb Exp Pharmacol,2012(207): 43-61.
[10]WONG G C,GIUGLIANO R P,ANTMAN E M. Use of low-molecularweight heparins in the management of acute coronary artery syndromes and percutaneous coronary intervention[J].JAMA,2003,289(3): 331-342.
[11]松田保.抗凝固疗法[J].综合临床,2003,52(5):1621-1623.
[12]ENGELBERG H,沈志祥.肝素、肝素成份和动脉粥样硬化[J].国外医学.心血管疾病分册,1986(1): 13-16.
[13]蒋婷婷,孙佳凤,夏江燕,等.肝素酶在内毒素血症致大鼠血管内皮糖萼破坏中的作用.中华麻醉学杂志,2015,35(9):1131-1131.
[14]王建军,黄寿吾,杨石强,等.肝素对小鼠实验性内毒素血症的保护作用[J].河南医学研究,1995(01):7-9.
[15]POMIN V H. Sulfated glycans in inflammation[J]. Eur J Med Chem,2015,92: 353-369.
[16]LEAN Q Y,ERI R D,RANDALL-DEMLLO S,et al. Orally administered enoxaparin ameliorates acute colitis by reducing macrophage-associated inflammatory responses[J]. PLoS One,2015,10(7): e0134259.
[17]HUANG J N,TSAI M C,FANG S L,et al. Low-molecular-weight heparin and unfractionated heparin decrease Th-1,2,and 17 expressions[J]. PLoS One,2014,9(11): e109996.
[18]FALANGA A,PANOVA-NOEVA M,RUSSO L. Procoagulant mechanisms in tumour cells[J]. Best Pract Res Clin Haematol,2009,22(1): 49-60.
[19]PONERT J M,GOCKEL L M,HENZE S,et al. Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells. Molecules. 2018; 23(10)
[20]LEBEAU B,CHASTANG C,BRECHOT J M,et al. Subcutaneous heparin treatment increases survival in small cell lung cancer.“Petites Cellules” Group[J]. Cancer,1994,74(1): 38-45.
[21]KIERAN M W,KALLURI R,CHO Y J. The VEGF pathway in cancer and disease: responses,resistance,and the path forward[J]. Cold Spring Harb Perspect Med,2012,2(12):a006593.
[22]LEUNG D W,CACHIANES G,KUANG W J,et al. Vascular endothelial growth factor is a secreted angiogenic mitogen[J].Science,1989,246(4935): 1306-1309.
[23]WANG X X. The development of new drug targeting hepcidin[J].Chin Pharm J,2018,53(6):405-410.
[24]STRELL C,ENTSCHLADEN F. Extravasation of leukocytes in comparison to tumor cells[J]. Cell Commun Signal,2008,6: 10.
[25]BORSIG L,WONG R,FERAMISCO J,et al. Heparin and cancer revisited: mechanistic connections involving platelets,P-selectin,carcinoma mucins,and tumor metastasis[J]. Proc Natl Acad Sci U S A,2001,98(6): 3352-3357.
[26]BORSIG L,WONG R,HYNES R O,et al. Synergistic effects of L-and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis[J]. Proc Natl Acad Sci U S A,2002,99(4): 2193-2198.
[27]YEUNG K T,YANG J. Epithelial-mesenchymal transition in tumor metastasis[J]. Mol Oncol,2017,11(1): 28-39.
[28]RICKLES F R,PATIERNO S,FERNANDEZ P M. Tissue factor,thrombin,and cancer[J]. Chest,2003,124(3 Suppl):58S-68S.
[29]WEILER J M,YURT R W,FEARON D T,et al. Modulation of the formation of the amplification convertase of complement,C3b,Bb,by native and commercial heparin[J]. J Exp Med,1978,147(2): 409-421.
[30]BAUGH C W,LEVINE M,CORNUTT D,et al. Anticoagulant Reversal Strategies in the Emergency Department Setting:Recommendations of a Multidisciplinary Expert Panel[J]. Ann Emerg Med,2020,76(4): 470-485.
[31]TOMASELLI G F,MAHAFFEY K W,CUKER A,et al. 2017 ACC expert consensus decision pathway on management of bleeding in patients on oral anticoagulants: a report of the American College of Cardiology Task Force on expert consensus decision pathways[J]. J Am Coll Cardiol,2017,70(24): 3042-3067.
[32]BOER C,MEESTERS M I,VEERHOEK D,et al. Anticoagulant and side-effects of protamine in cardiac surgery: a narrative review[J]. Br J Anaesth,2018,120(5): 914-927.
[33]SOKOLOWSKA E,KALASKA B,MIKLOSZ J,et al. The toxicology of heparin reversal with protamine: past,present and future[J].Expert Opin Drug Metab Toxicol,2016,12(8): 897-909.
[34]APPLEFIELD D,KRISHNAN S. PROTAMINE [M]. Treasure Island(FL): StatPearls ,2020.
[35]CARR J A,SILVERMAN N. The heparin-protamine interaction.A review[J]. J Cardiovasc Surg(Torino),1999,40(5): 659-666.
[36]KITANI T,NAGARAJAN S C,SHANBERGE J N. Effect of protamine on heparin antithrombin Ⅲ complexes. In vivo studies[J].Thromb Res,1980,17(3/4): 375-382.
[37]OKAJIMA Y,KANAYAMA S,MAEDA Y,et al. Studies on the neutralizing mechanism of antithrombin activity of heparin by protamine[J]. Thromb Res,1981,24(1/2): 21-29.
[38]STEHLE G,WUNDER A,SINN H,et al. Complexes of a modified low-molecular-weight heparin with protamine are predominantly cleared by a macrophage scavenger receptormediated process in rats[J]. J Surg Res,1995,58(2): 197-204.
[39]PAI M,CROWTHER M A. Neutralization of heparin activity[J].Handb Exp Pharmacol,2012(207): 265-277.
[40]SIMON E M,STREITZ M J,SESSIONS D J,et al. Anticoagulation reversal[J]. Emerg Med Clin North Am,2018,36(3): 585-601.
[41]MOCHIZUKI T,OLSON P J,SZLAM F,et al. Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass[J]. Anesth Analg,1998,87(4): 781-785.
[42]BARSTAD R M,STEPHENS R W,HAMERS M J,et al. Protamine sulphate inhibits platelet membrane glycoprotein Ib-von Willebrand factor activity[J]. Thromb Haemost,2000,83(2):334-337.
[43]BOLLIGER D,SZLAM F,AZRAN M,et al. The anticoagulant effect of protamine sulfate is attenuated in the presence of platelets or elevated factor Ⅷ concentrations[J]. Anesth Analg,2010,111(3): 601-608.
[44]KHAN N U,WAYNE C K,BARKER J,et al. The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph[J]. Eur J Anaesthesiol,2010,27(7): 624-627.
[45]NI AINLE F,PRESTON R J,JENKINS P V,et al. Protamine sulfate down-regulates thrombin generation by inhibiting factorⅤ activation[J]. Blood,2009,114(8): 1658-1665.
[46]OLSSON A,ALFREDSSON J,HåKANSSON E,et al. Protamine reduces whole blood platelet aggregation after cardiopulmonary bypass[J]. Scand Cardiovasc J,2016,50(1): 58-63.
[47]KIMMEL S E,SEKERES M,BERLIN J A,et al. Mortality and adverse events after protamine administration in patients undergoing cardiopulmonary bypass[J]. Anesth Analg,2002,94(6): 1402-1408,table of contents.
[48]KATZ N M,KIM Y D,SIEGELMAN R,et al. Hemodynamics of protamine administration. Comparison of right atrial,left atrial,and aortic injections[J]. J Thorac Cardiovasc Surg,1987,94(6): 881-886.
[49]NYBO M,MADSEN J S. Serious anaphylactic reactions due to protamine sulfate: a systematic literature review[J]. Basic Clin Pharmacol Toxicol,2008,103(2): 192-196.
[50]SAITO T,SUMITHRAN E,GLASGOW E F,et al. The enhancement of aminonucleoside nephrosis by the co-administration of protamine[J]. Kidney Int,1987,32(5): 691-699.
[51]VEHASKARI V M,ROOT E R,GERMUTH F G JR,et al. Glomerular charge and urinary protein excretion: effects of systemic and intrarenal polycation infusion in the rat[J]. Kidney Int,1982,22(2): 127-135.
[52]HIRD R B,WAKEFIELD T W,MUKHERJEE R,et al. Direct effects of protamine sulfate on myocyte contractile processes.Cellular and molecular mechanisms[J]. Circulation,1995,92(9 Suppl): Ⅱ433-Ⅱ446.
[53]HORROW J C. Protamine: a review of its toxicity[J]. Anesth Analg,1985,64(3): 348-361.
[54]CHUDASAMA S L,ESPINASSE B,HWANG F,et al. Heparin modifies the immunogenicity of positively charged proteins[J].Blood,2010,116(26): 6046-6053.
[55]WEISS M E,NYHAN D,PENG Z K,et al. Association of protamine IgE and IgG antibodies with life-threatening reactions to intravenous protamine[J]. N Engl J Med,1989,320(14):886-892.
[56]MOREL D R,LOWENSTEIN E,NGUYENDUY T,et al. Acute pulmonary vasoconstriction and thromboxane release during protamine reversal of heparin anticoagulation in awake sheep.Evidence for the role of reactive oxygen metabolites following nonimmunological complement activation[J]. Circ Res,1988,62(5): 905-915.
[57]BUTTERWORTH J,LIN Y A,PRIELIPP R,et al. The pharmacokinetics and cardiovascular effects of a single intravenous dose of protamine in normal volunteers[J]. Anesth Analg,2002,94(3):514-522; table of contents.
[58]GALEONE A,ROTUNNO C,GUIDA P,et al. Monitoring incomplete heparin reversal and heparin rebound after cardiac surgery[J]. J Cardiothorac Vasc Anesth,2013,27(5): 853-858.
[59]国家食品药品监督管理总局.总局关于修订鱼精蛋白注射液说明书的公告(2016年第53号) [A/OL].(2016-03-09)[2022-11-03].https://www.nmpa.gov.cn/xxgk/ggtg/qtggtg/20160309160601840.html
[60]陈桐,陈庆伟.血小板第四因子与心脑血管疾病[J].现代医药卫生,2008,24(12):1842-1843.
[61]杜顺波,方利华.老年多灶性脑梗死患者血浆血小板第4因子变化及其临床意义[J].中国老年学杂志,2015,35(23):6756-6757.
[62]MIXON T A,DEHMER G J. Recombinant platelet factor 4 for heparin neutralization[J]. Semin Thromb Hemost,2004,30(3): 369-377.
[63]COOK J J,NIEWIAROWSKI S,YAN Z,et al. Platelet factor 4 efficiently reverses heparin anticoagulation in the rat without adverse effects of heparin-protamine complexes[J]. Circulation,1992,85(3): 1102-1109.
[64]DEHMER G J,FISHER M,TATE D A,et al. Reversal of heparin anticoagulation by recombinant platelet factor 4 in humans[J].Circulation,1995,91(8): 2188-2194.
[65]DEHMER G J,LANGE R A,TATE D A,et al. Randomized trial of recombinant platelet factor 4 versus protamine for the reversal of heparin anticoagulation in humans[J]. Circulation,1996,94(9 Suppl): Ⅱ347-Ⅱ352.
[66]HEDNER U. Recombinant activated factor Ⅶ: 30 years of research and innovation[J]. Blood Rev,2015,29 Suppl 1:S4-S8.
[67]VAVRA K A,LUTZ M F,SMYTHE M A. Recombinant factorⅦa to manage major bleeding from newer parenteral anticoagulants[J]. Ann Pharmacother,2010,44(4): 718-726.
[68]YOUNG G,YONEKAWA K E,NAKAGAWA P A,et al. Recombinant activated factor Ⅶ effectively reverses the anticoagulant effects of heparin,enoxaparin,fondaparinux,argatroban,and bivalirudin ex vivo as measured using thromboelastography[J]. Blood Coagul Fibrinolysis,2007,18(6): 547-553.
[69]SIEGAL D M,CURNUTTE J T,CONNOLLY S J,et al. Andexanet alfa for the reversal of factor Ⅹa inhibitor activity[J]. N Engl J Med,2015,373(25): 2413-2424.
[70]MANENO J N,NESS G L. Andexanet alfa,the possible alternative to protamine for reversal of unfractionated heparin[J]. Ann Pharmacother,2021,55(2): 261-264.
[71]LAULICHT B,BAKHRU S,LEE C,et al. Small molecule antidote for anticoagulants [J]. Circulation,2012,126(Suppl 21): 11395.
[72]ANSELL J E,BAKHRU S H,LAULICHT B E,et al. Use of PER977 to reverse the anticoagulant effect of edoxaban[J]. N Engl J Med,2014,371(22): 2141-2142.
[73]ANSELL J E,LAULICHT B E,BAKHRU S H,et al. Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin[J]. Thromb Res,2016,146: 113-118.
[74]WEITZ J I,EIKELBOOM J W. Ciraparantag for enoxaparin reversal: Adding to the evidence[J]. Thromb Res,2016,146:106-107.